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1

Lysosomotropic agents

Christian De Duve, Thierry De Barsy, Brian Poole, Andre´ Trouet, Paul Tulkens, Fran¸ois Van Hoof

Journal:

Biochemical Pharmacology

Year:

1974

Language:

english

File:

PDF, 6.15 MB

english, 1974

2

The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase

Siala, Wafi, Kucharíková, Soňa, Braem, Annabel, Vleugels, Jef, Tulkens, Paul M, Mingeot-Leclercq, Marie-Paule, Van Dijck, Patrick, Van Bambeke, Françoise

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 2.69 MB

english, 2016

3

Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic

Sophie Denamur, Donatienne Tyteca, Jacqueline Marchand-Brynaert, Françoise Van Bambeke, Paul M. Tulkens, Pierre J. Courtoy, Marie-Paule Mingeot-Leclercq

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 2.74 MB

english, 2011

4

Gentamicin-induced apoptosis in LLC-PK1 cells: Involvement of lysosomes and mitochondria

Hélène Servais, Patrick Van Der Smissen, Gaëtan Thirion, Gauthier Van der Essen, Françoise Van Bambeke, Paul M. Tulkens, Marie-Paule Mingeot-Leclercq

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 602 KB

english, 2005

5

Optimizing β-lactams treatment in critically-ill patients using pharmacokinetics/pharmacodynamics targets: are first conventional doses effective?

Delattre, Isabelle K., Taccone, Fabio S., Jacobs, Frédérique, Hites, Maya, Dugernier, Thierry, Spapen, Herbert, Laterre, Pierre-François, Wallemacq, Pierre E., Van Bambeke, Françoise, Tulkens, Paul M.

Journal:

Expert Review of Anti-infective Therapy

Year:

2017

Language:

english

File:

PDF, 827 KB

english, 2017

6

A Comparison of Nephrotoxicity in Non–Intensive Care Unit Medical/Surgical Patients Receiving Vancomycin Alone Versus Vancomycin With Piperacillin-Tazobactam—Do We Need to Ban This Combination ?

Tulkens, Paul M.

Journal:

Infectious Disease in Clinical Practice

Year:

2018

Language:

english

File:

PDF, 77 KB

english, 2018

7

Loss of activity of ceftazidime-avibactam due to Mex-AB-OprM efflux and overproduction of AmpC cephalosporinase in Pseudomonas aeruginosa isolated from patients suffering from cystic fibrosis

Chalhoub, Hussein, Sáenz, Yolanda, Nichols, Wright W., Tulkens, Paul M., Van Bambeke, Françoise

Journal:

International Journal of Antimicrobial Agents

Year:

2018

Language:

english

File:

PDF, 620 KB

english, 2018

8

Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Oumar, Aboubacar Alassane, Abdoulaye, Amadou, Maiga, Mamoudou, Sidibe, Younoussa, Cissoko, Yacouba, Konate, Issa, Diarra, Maimouna, Sangho, Fanta, Dembele, Jean Paul, Tulkens, Paul M, Dao, Sounkalo

Journal:

Journal of Pharmacovigilance

Year:

2017

Language:

english

File:

PDF, 792 KB

english, 2017

9

Antibiotic Resistance, Biofilm Formation, and Intracellular Survival As Possible Determinants of Persistent or Recurrent Infections by Staphylococcus aureus in a Vietnamese Tertiary Hospital: Focus on Bacterial Response to Moxifloxacin

Nguyen, Tiep Khac, Argudín, Maria A., Deplano, Ariane, Nhung, Pham Hong, Nguyen, Hoang Anh, Tulkens, Paul M., Dodemont, Magali, Van Bambeke, Françoise

Journal:

Microbial Drug Resistance

Year:

2019

File:

PDF, 247 KB

2019

10

Interactions of aminoglycosides with phosphatidylinositol: A 15N nuclear magnetic resonance study

André Schanck, Robert Brasseur, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens

Journal:

Magnetic Resonance in Chemistry

Year:

1992

Language:

english

File:

PDF, 464 KB

english, 1992

11

Interactions of aminoglycoside antibiotics with phospholipids. A deuterium nuclear magnetic resonance study

André Schanck, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens, Danielle Carrier, Ian C.P. Smith, Harold C. Jarrell

Journal:

Chemistry and Physics of Lipids

Year:

1992

Language:

english

File:

PDF, 860 KB

english, 1992

12

Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(β-diethylaminoethylether)hexestrol) and aggregating (spermine) agents

Françoise van Bambeke, Marie-Paule Mingeot-Leclercq, Robert Brasseur, Paul M. Tulkens, André Schanck

Journal:

Chemistry and Physics of Lipids

Year:

1996

Language:

english

File:

PDF, 942 KB

english, 1996

13

Comparative toxicity of aminoglycoside antibiotics towards the lysosomes in a cell culture model

Paul Tulkens, François Van Hoof

Journal:

Year:

1980

Language:

english

File:

PDF, 229 KB

english, 1980

14

Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensor

Olivier Hernout, Karine Berthoin, Isabelle Delattre, Paul M. Tulkens, Stéphane Carryn, Jacqueline Marchand-Brynaert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 325 KB

english, 2007

15

Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids

Jocelyne Piret, André Schanck, Sylvie Delfosse, Françoise Van Bambeke, Bellamkonda K. Kishore, Paul M. Tulkens, Marie-Paule Mingeot-Leclercq

Journal:

Chemistry and Physics of Lipids

Year:

2005

Language:

english

File:

PDF, 189 KB

english, 2005

16

Syntheses and hydrolysis of basic and dibasic ampicillin esters tailored for intracellular accumulation

Isabelle Paternotte, Hua Juan Fan, Pascal Scrève, Michel Claesen, Paul M Tulkens, Etienne Sonveaux

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 291 KB

english, 2001

17

Molecular models of human P-glycoprotein in two different catalytic states

Jean-Paul Becker, Grégoire Depret, Françoise Van Bambeke, Paul M Tulkens, Martine Prévost

Journal:

BMC Structural Biology

Year:

2009

Language:

english

File:

PDF, 3.23 MB

english, 2009

18

Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity ofListeria monocytogenes

Sébastien Van de Velde, Stéphane Carryn, Françoise Van Bambeke, Colin Hill, Paul M Tulkens, Roy D Sleator

Journal:

Year:

2009

Language:

english

File:

PDF, 640 KB

english, 2009

19

Isolation and 2-D-DIGE proteomic analysis of intracellular and extracellular forms of Listeria monocytogenes

Sébastien Van de Velde, Edouard Delaive, Marc Dieu, Stéphane Carryn, Françoise Van Bambeke, Bart Devreese, Martine Raes, Paul M. Tulkens

Journal:

Year:

2009

Language:

english

File:

PDF, 351 KB

english, 2009

20

Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: Insight into the mechanism of ligand migration and binding sites

Stéphane Vandevuer, Françoise Van Bambeke, Paul M. Tulkens, Martine Prévost

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 831 KB

english, 2006

21

Structure-Based Design of Benzoxazoles as new Inhibitors for D-Alanyl – D-Alanine Ligase

Isabelle Tytgat, Stéphane Vandevuer, Isabelle Ortmans, Finton Sirockin, Evelina Colacino, Françoise Van Bambeke, Colette Duez, Jacques H. Poupaert, Paul M. Tulkens, Annick Dejaegere, Martine Prévost

Journal:

Molecular Informatics

Year:

2009

Language:

english

File:

PDF, 513 KB

english, 2009

22

Biophysical studies and intracellular destabilization of pH-sensitive liposomes

Fran¢oise Van Bambeke, Anne Kerkhofs, André Schanck, Claude Remacle, Etienne Sonveaux, Paul M. Tulkens, Marie-Paule Mingeot-Leclercq

Journal:

Year:

2000

Language:

english

File:

PDF, 1.08 MB

english, 2000

23

Tissue injury and proliferative response induced in rat kidney by cis-diamminedichloroplatinum (II)

Guy Laurent, Virginie Yernaux, Denis Nonclercq, Gérard Toubeau, Paul Maldague, Paul M. Tulkens, Jeanine A. Heuson-Stiennon

Journal:

Virchows Archiv B Cell Pathology Zell-pathologie

Year:

1988

Language:

english

File:

PDF, 9.30 MB

english, 1988

24

Effect of a Collaborative Approach on the Quality of Prescribing for Geriatric Inpatients: A Randomized, Controlled Trial

Anne Spinewine, Christian Swine, Soraya Dhillon, Philippe Lambert, Jean B. Nachega, Léon Wilmotte, Paul M. Tulkens

Journal:

Journal of the American Geriatrics Society

Year:

2007

Language:

english

File:

PDF, 108 KB

english, 2007

25

Immunological Inhibition of Lysosome Function

TULKENS, PAUL, TROUET, ANDRÉ, VAN HOOF, FRANÇOIS

Journal:

Year:

1970

File:

PDF, 632 KB

1970

26

Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats

Giuliano, Rubén A, Paulus, Guy J, Verpooten, Gert A, Pattyn, Viviane M, Pollet, Dirk E, Nouwen, Etienne J, Laurent, Guy, Carlier, Marie-Béatrice, Maldague, Paul, Tulkens, Paul M

Journal:

Kidney International

Year:

1984

Language:

english

File:

PDF, 1.32 MB

english, 1984

27

Early effects of gentamicin, tobramycin, and amikacin on the human kidney

De Broe, Marc E, Paulus, Guy J, Verpooten, Gert A, Roels, Frank, Buyssens, Norbert, Wedeen, Richard, Van Hoof, François, Tulkens, Paul M

Journal:

Kidney International

Year:

1984

Language:

english

File:

PDF, 1.24 MB

english, 1984

28

Distribution of epidermal growth factor in the kidneys of rats exposed to amikacin

Toubeau, Gérard, Nonclercq, Denis, Zanen, Jacqueline, Lambricht, Patrick, Tulkens, Paul M, Heuson-Stiennon, Jeanine-Anne, Laurent, Guy

Journal:

Kidney International

Year:

1991

Language:

english

File:

PDF, 1.21 MB

english, 1991

29

Cell Handling, Membrane-Binding Properties and Membrane-Penetration Modeling Approaches of Pivampicillin and Phthalimidomethylampicillin, Two Basic Esters of Ampicillin, in Comparison with Chloroquine and Azithromycin

Hugues Chanteux, Isabelle Paternotte, Marie-Paule Mingeot-Leclercq, Robert Brasseur, E. Sonveaux, Paul M. Tulkens

Journal:

Pharmaceutical Research

Year:

2003

Language:

english

File:

PDF, 200 KB

english, 2003

30

Tissue injury and repair in the rat kidney after exposure to cisplatin or carboplatin

Denis Nonclercq, Gérard Toubeau, Guy Laurent, Paul M. Tulkens, Jeanine A. Heuson-Stiennon

Journal:

Experimental and Molecular Pathology

Year:

1989

Language:

english

File:

PDF, 8.50 MB

english, 1989

31

Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells

Françoise Van Bambeke, Marie-Paule Mingeot-Leclercq, André Schanck, Robert Brasseur, Paul M. Tulkens

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.38 MB

english, 1993

32

Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes

Françoise Van Bambeke, Paul M. Tulkens, Robert Brasseur, Marie-Paule Mingeot-Leclercq

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.17 MB

english, 1995

33

Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1

Marie-Cécile Nassogne, Chantal Lizarraga, Francisca N'Kuli, Françoise Van Bambeke, Roger Van Binst, Pierre Wallemacq, Paul M Tulkens, Marie-Paule Mingeot-Leclercq, Thierry Levade, Pierre J Courtoy

Journal:

Toxicology and Applied Pharmacology

Year:

2004

Language:

english

File:

PDF, 396 KB

english, 2004

34

Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin

Coralie M. Vallet, Béatrice Marquez, Naïma Nhiri, Ahalieyah Anantharajah, Marie-Paule Mingeot-Leclercq, Paul M. Tulkens, Jean-Yves Lallemand, Eric Jacquet, Françoise Van Bambeke

Journal:

Year:

2011

Language:

english

File:

PDF, 579 KB

english, 2011

35

Antibiotic efflux pumps

Françoise Van Bambeke, Elisabetta Balzi, Paul M Tulkens

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 488 KB

english, 2000

36

Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts

Donatienne Tyteca, Patrick Van Der Smissen, Françoise Van Bambeke, Karin Leys, Paul M. Tulkens, Pierre J. Courtoy, Marie-Paule Mingeot-Leclercq

Journal:

European Journal of Cell Biology

Year:

2001

Language:

english

File:

PDF, 259 KB

english, 2001

37

Dynamics and Structural Changes Induced by ATP Binding in SAV1866, a Bacterial ABC Exporter

Becker, Jean-Paul, Van Bambeke, Françoise, Tulkens, Paul M., Prévost, Martine

Journal:

Journal of Physical Chemistry B

Year:

2010

Language:

english

File:

PDF, 606 KB

english, 2010

38

Azithromycin, a Lysosomotropic Antibiotic, Has Distinct Effects on Fluid-Phase and Receptor-Mediated Endocytosis, but Does Not Impair Phagocytosis in J774 Macrophages

Donatienne Tyteca, Patrick Van Der Smissen, Marcel Mettlen, Françoise Van Bambeke, Paul M. Tulkens, Marie-Paule Mingeot-Leclercq, Pierre J. Courtoy

Journal:

Experimental Cell Research

Year:

2002

Language:

english

File:

PDF, 446 KB

english, 2002

39

Experimental studies on nephrotoxicity of aminoglycosides at low doses: Mechanisms and perspectives

Paul M. Tulkens

Journal:

The American Journal of Medicine

Year:

1986

Language:

english

File:

PDF, 6.49 MB

english, 1986

40

The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts

Paul Tulkens, AndrÉ Trouet

Journal:

Biochemical Pharmacology

Year:

1978

Language:

english

File:

PDF, 1.08 MB

english, 1978

41

Mechanism of aminoglycoside-induced lysosomal phospholipidosis: In vitro and in vivo studies with Gentamicin and Amikacin

Guy laurent, Marie-Béatrice Carlier, Bruno Rollman, Frano̧is Van Hoof, Paul Tulkens

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 1.16 MB

english, 1982

42

Interactions of aminoglycoside antibiotics with negatively charged lipid layers: Biochemical and conformational studies

Robert Brasseur, Guy Laurent, Jean Marie Ruysschaert, Paul Tulkens

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 965 KB

english, 1984

43

Biochemical mechanism of aminoglycoside-induced inhibition of phosphatidylcholine hydrolysis by lysosomal phospholipases

Marie-Paule Mingeot-Leclercq, Guy Laurent, Paul M. Tulkens

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 1.03 MB

english, 1988

44

Ultrastructural, physico-chemical and conformational study of the interactions of gentamicin and bis(beta-diethylaminoethylether)hexestrol with negatively-charged phospholipid layers

Marie-Paule Mingeot-Leclercq, André Schanck, Marie-France Ronveaux-Dupal, Michel Deleers, Robert Brasseur, Jean-Marie Ruysschaert, Guy Laurent, Paul M. Tulkens

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 2.75 MB

english, 1989

45

Aminoglycoside-induced renal phospholipidosis and nephrotoxicity

Guy Laurent, Bellamkonda K. Kishore, Paul M. Tulkens

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.23 MB

english, 1990

46

Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition induced by aminoglycoside antibiotics—II: Conformational analysis

Marie-Paule Mingeot-Leclercq, Jocelyne Piret, Paul M. Tulkens, Robert Brasseur

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.10 MB

english, 1990

47

Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics—I: Biochemical analysis

Marie-Paule Mingeot-Leclercq, Jocelyne Piret, Robert Brasseur, Paul M. Tulkens

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.37 MB

english, 1990

48

Effect of substrate organization on the activity and on the mechanism of gentamicin-induced inhibition of rat liver lysosomal phospholipase A1

Jocelyne Piret, Bellamkonda K. Kishore, Paul M. Tulkens

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 472 KB

english, 1992

49

Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation

Cécile Gerbaux, Françoise Van Bambeke, Jean-Pierre Montenez, Jocelyne Piret, Grégory Morlighem, Paul M. Tulkens

Journal:

Year:

1996

Language:

english

File:

PDF, 376 KB

english, 1996

50

Interactions of ciprofloxacin with DPPC and DPPG: Fluorescence anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis

Hayet Bensikaddour, Karim Snoussi, Laurence Lins, Françoise Van Bambeke, Paul M. Tulkens, Robert Brasseur, Erik Goormaghtigh, Marie-Paule Mingeot-Leclercq

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2008

Language:

english

File:

PDF, 713 KB

english, 2008